Human African trypanosomiasis (HAT), or sleeping sickness, is a parasitic infection that is endemicin sub-Saharan Africa and is almost invariably fatal unless treated.The infection is transmitted to humans through the bite of an infected tsetse fly. The parasitemultiplies in the lymph and blood, causing unspecific symptoms and signs (first-stage or haemolymphatic stage) and, over time, crosses the blood–brain barrier to infect the central nervoussystem (second-stage or meningo-encephaliti
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