: income countries were heavilydependent on high-income countries (HICs) and international organizations for vaccinesupply, resulting in global competition for vaccines and huge inequities. Achieving vaccinesecurity and self-sufficiency is of high importance to Southeast Asia. To achieve this goal,the Association of Southeast Asian Nations (ASEAN) established the ASEAN VaccineSecurity and Self-Reliance (AVSSR) initiative. Building on the efforts of ASEAN leadership,the World Bank commis